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Preimplantion Genetic Diagnosis



What is Preimplantion Genetic Diagnosis?


Preimplantation genetic diagnosis (PGD) is a reproductive technology used along with an IVF cycle to increase the potential for a successful pregnancy and delivery. 

PGD is a genetic test on cells removed from embryos, to help select the best embryo(s) to achieve pregnancy or to avoid a genetic disease for which a couple is at risk.



PGD

Preimplantion Genetic Diagnosis

Who should consider PGD?

Who should consider PGD?


PGD may be considered in all IVF cycles; however, those who might benefit most from this test are :

Couples at increased risk for chromosome abnormalities or specific genetic disorders.

Women who have had several miscarriages, or who have had a prior pregnancy with a chromosome abnormality.

This test is also known as PGT-A (aneuploidy).

PGS (PGT-A) is carried out:

  • to screen the entire set of chromosomes for abnormalities
  • to improve IVF results;
  • to increase IVF success rates;
  • without personalized test preparation 

Women over 38 years of age and men with some types of sperm abnormalities may produce embryos with higher rates of chromosome abnormalities. 

PGT-SR / PGT-M  

If a person carries a structural rearrangement of the chromosomes, PGD can identify which embryos have a normal amount of chromosomal material.

This technology is also known as PGT-SR (structural rearrangement).

When there is a 25% or 50% chance to have a child affected with a specific genetic disease, PGD can be designed to identify which embryos are affected, unaffected, or a carrier (if applicable) for that disease.

Then, only embryos without the disease are transferred to the uterus to attempt pregnancy.

This is also known as PGT-M (monogenic disorders). 


PGD (PGT-M) is carried out:


  • To reduce genetic disorder risk;
  • To check for monogenic hereditary diseases 
  • With personalized test design & preparation